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Mechanistically, glucose depletion reduces phosphatidylinositol (4,5)-bisphosphate levels in the Golgi apparatus, thereby disrupting the assembly of the CUL7-FBXW8 E3 ubiquitin ligase complex, a key regulator of ATGL degradation

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More severe emphysema symptoms were correlated with the degree of change in gene expression

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Supplementary material The Supplementary Material for this article can be found online at: References 1 BeckmanK

Shaw JE, Zimmet PZ, de Courten M, Dowse GK, Chitson P, Gareeboo H, Hemraj F, Fareed D, Tuomilehto J, Alberti KG